Toxic Waste Bunny was a regular bunny who found his way into a landfill. After being dunked in toxic waste, he came out taller, multicolored, with three ears, two and a half arms, and another eyeball. Today, Toxic Waste Bunny is a celebrity and heads a large company known as Toxic Waste Industries. They invent new uses for Toxic Waste and possum fur.

Toxic Waste Bunny is also well-known on television. His first show was known as Off-Ramp, hosted by TWB underneath a highway exit. After three seasons, Off-Ramp moved to the Toxic Waste Bunny Network, aimed at the possum population. It also has such shows as Wheel of Luncheon, where possums spin a wheel and eat whatever is on that part of the wheel if the possum guesses a letter in the word "possum". Other shows include Grandpa Earl's The Legend of Rope, Late Night with Toxic Waste Bunny, Eye Pus Cooking with Alfred Chipmunk, Polluted Possum Show, Survivor: Possum, Brillo Pads, and Possum Olympics.