Funny you should mention this just now, because I am at this time working on a comic series. Although, this one is mostly serious and is pretty much an epic graphic novel/manga type (released in installments) that is hand-drawn. However, I am planning to release a regular comic strip type series along with it, though I haven't figured out whether I should put them in the same topic or in seperate ones. Guess it all comes down to how active I am with the humor series.
The "comic strip" series would also be hand-drawn, mainly because I suck at digital manipulation, but I may throw in some sprite comics if I either a) find time to figure out GIMP or B) find out if it's possible to make sprite comics on Corel.
For anyone interested, I've begun work on the first chapter and should begin publishing when I get to the 2nd or 3rd. [/blatantselfplug]
@MirMir: Well, I guess we could make super impressive comics and advertise them in our siggies with really impressive graphics (or really cute characters).
...
Eh, pathetic and uncreative. >_<;